The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Stephen I. Katz Early Stage Investigator Research Project Grant (R01). The grant is suitable for early-stage investigators who wish to initiate a research project in an area different from their previous research focus and/or training experience. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. Key aspects of the grant include: • The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. • The proposed project must be a change in research direction for the early-stage investigator. • The grant is not suitable for incremental advancements, expansions, or extensions of previous research efforts. • Potential applicants are strongly encouraged to contact a program director to discuss their proposed project. • The grant is available to various types of organizations, including non-profits, small businesses, and institutions of higher education.