Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional)

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications that will expand knowledge of the natural history of disorders that currently are, or may become, part of statewide newborn screening programs. This includes characterization of the sequence and timing of symptom development, establishment of genotype-phenotype correlations, and identification of modifying genetic, epigenetic, or environmental factors. The goal is to facilitate appropriate interventions for infants identified by newborn screening and to improve diagnostic accuracy, clinical trials, and treatment outcomes. • The opportunity is open to various applicant types, including public and state-controlled institutions of higher education, non-profits, small businesses, and others. • The funding instrument is a grant, and the funding activity categories are Health and Income Security and Social Services. • The expected application count is 100, and the expected application size is 0. • The opportunity is electronic and requires the use of the eRA Service Desk for support.