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National Science Foundation·Virginia

NSF X-Labs Initiative - From Sequence to Function

Closes 2/8/2027$1.5M – $150MRequest for Proposal
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Description

The National Science Foundation’s X‑Labs initiative seeks full‑time, multidisciplinary R&D teams to develop platform technologies that translate protein or genome sequences into predictable, engineerable functions. The effort is funded through Other Transaction contracts and is structured in Phase 0 (proof‑of‑concept) followed by Phase 1 (scale‑up) with milestone‑based payments. Proposers must submit an 8‑page written proposal and a separate COI statement, and may ask questions until mid‑December 2026. • Targeted domain: bioengineering platforms for protein‑sequence‑to‑function or genome‑to‑function technologies, including AI/ML‑driven design. • Funding ceiling: up to $1.5 M for Phase 0 and up to $50 M per year for Phase 1, with total project length potentially 2–3 years. • Eligibility: any U.S. entity (university, nonprofit, private firm) capable of leading a full‑time R&D team; senior/key personnel can appear on only one proposal. • Required deliverables: mission statement, technology landscape analysis, measurable outcomes, senior personnel bios, team capability statement, biosafety/biosecurity plan, and milestone plans.

Attached files

Contact

X-Labs

[email protected]

Key dates

Opened
10/14/2026
Questions due
12/14/2026
Closes
2/8/2027
Duration
30 months

Last updated

Details

Type
Request for Proposal
Industry
Engineering Services
NAICS
541714
Solicitation №
NSF-Topic4-FY26-XLabsSequence-to-Function

Budget estimate

$1,500,000 – $150,000,000

The award structure allows up to $1.5 M for the 9‑month Phase 0 effort and up to $50 M per year for the subsequent 24‑36 month Phase 1. Assuming a typical Phase 1 duration of about 30 months, total potential funding could range from the $1.5 M baseline up to roughly $150 M if the maximum annual budget is fully utilized. Realistically, most awards fall in the mid‑range (e.g., $5‑20 M) depending on team scope and milestone achievements.

AI estimate from the solicitation

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