GREGoRi Innovation Projects (U01 Clinical Trial Optional)

The Genomics Research to Elucidate the Genetics of Rare Diseases: innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies, and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art. • The GREGoRi initiative aims to support research that accelerates foundational resources, technology development, and experimental and computational approaches for basic genomics and functional genomics research. • The initiative also aims to support the application of genomics to medical science and clinical care, and to support ethical, legal, and social implications (ELSI) research concerning societal issues that need to be addressed, especially as genomic science advances. • The National Human Genome Research Institute (NHGRI) will be responsible for the normal scientific and programmatic stewardship of the award, and will be named in the award notice. • The GREGoRi Research Consortium will be governed by a Steering Committee, which will be composed of the PD/PI(s) from each of the funded research groups and NIH program staff.