Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults (R34 Clinical Trial Required)

The National Institutes of Health (NIH) is seeking applications for pilot research to adapt, optimize, and test behavioral interventions that address common sleep problems in adolescents and young adults with or at risk for a mental health disorder. This notice of funding opportunity (NOFO) supports pilot clinical trials designed to evaluate the feasibility, tolerability, acceptability, safety, and potential effectiveness of the approach in real-world settings. Applications should aim to conduct a preliminary test of the intervention's impact on sleep and mental health outcomes, as well as an examination of the mechanisms that underlie the intervention's effectiveness, and to obtain preliminary data needed as a prerequisite for larger-scale effectiveness trials. Some key aspects of this opportunity include: • The estimated funding for this opportunity is $1,500,000. • The application submission deadline is October 22, 2026. • The project start date is estimated to be July 1, 2026. • The opportunity is open to various types of organizations, including for-profit organizations, non-profits, and institutions of higher education. • The application process involves submitting a proposal through the NIH ASSIST system or Grants.gov. • The review process will evaluate the application based on factors such as significance, investigators, innovation, approach, and environment. • The award will be made as a grant, and the recipient will be responsible for conducting the research and submitting progress reports. • The opportunity is subject to various terms and conditions, including those related to data management and sharing, reporting, and financial management.