ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

The ARPA‑H COSMOS initiative seeks to determine whether micro‑gravity accelerates tissue aging and to build a high‑throughput, autonomous drug‑screening platform in low‑Earth orbit. Proposers must design, produce, and manage large numbers of microphysiological systems (MPS) or organoids from healthy donors, conduct a twin study (ground vs. flight) with autonomous flight lasting four weeks, and partner with at least one Fortune‑100 biopharma company. The effort is split into a 27‑month Phase I (including two LEO launches) and an optional 15‑month Phase II for disease‑model screening, with extensive multi‑omics data generation, in‑silico aging models, and mandatory data‑sharing. No hardware or flight services are in scope for technical performers; those will be handled by separate commercial service providers.