The Missile Defense Agency (MDA) is seeking innovative concepts, technological innovations, prototype demonstrations, and scientific breakthroughs to enhance the robustness and effectiveness of the Missile Defense System. The agency is interested in the rapid development of cutting-edge, disruptive technologies to revolutionize missile defense capabilities. The announcement includes topic areas such as kinetic and hypersonic defense, command and control battle management, integrated non-kinetic and electronic warfare, and disruptive technologies. • Kinetic and Hypersonic Defense: development of cost-efficient kinetic defense solutions against ballistic and hypersonic missile threats • Command and Control Battle Management: enhancement of missile defense effectiveness through innovative and disruptive technologies • Integrated Non-Kinetic and Electronic Warfare: development of scalable, multi-domain non-kinetic and electronic warfare capabilities • Disruptive Technologies: incorporation of mature, disruptive technologies to rapidly field advanced capabilities • Space-based Sensors, Interceptors, and Effectors: development of disruptive technologies to maintain space domain awareness superiority • Digital Revolution: development and integration of advanced analytics, including AI/ML, to enhance all aspects of missile defense • Radiation Effects, Heavy Ion, Proton, and Pulsed Neutron Single Event Effects on Electronic Devices and Systems: development of new single event effects test methodologies and techniques • International Missile Defense System Cooperation: efforts to work directly with foreign companies, entities, or universities as partners or major subcontractors