The Mathematical Biology Program supports research in areas of applied and computational mathematics with relevance to the biological sciences. Successful proposals must demonstrate mathematical innovation, biological relevance and significance, and strong integration between mathematics and biology. Some projects of interest to the Mathematical Biology Program may include development of mathematical concepts and tools traditionally seen in other disciplinary programs within the Division of Mathematical Sciences. • The program regularly seeks joint reviews of proposals with programs in the Directorates of Biological Sciences and Engineering. • Investigators are encouraged to discuss their project with program officers in relevant areas to determine if it should be considered by more than one program. • Research in Undergraduate Institutions (RUI) proposals should read the RUI solicitation, as the rules for proposal format may deviate from the Proposal & Award Policies & Procedures Guide (PAPPG). • EAGER and RAPID Proposals require prior contact with the cognizant program directors. • Requests for Award Supplements require prior contact with the cognizant program director. • Conferences and workshops proposals should carefully read the program solicitation to obtain important information regarding the substance of proposals.