The Shared Instrumentation Grant (SIG) Program is a funding opportunity that aims to consolidate three existing shared-use instrumentation programs. The program invites applications from groups of NIH-supported investigators to purchase or upgrade a single item of state-of-the-art commercially available instrument or an integrated instrumentation system. The instruments purchased through the SIG Program require optimal sharing among users to ensure efficient and cost-effective research operations, enable rigorous and reproducible measurements, and encourage collaborative research and benefit broad research communities at large. The key aspects of this opportunity include: • The minimum award is $300,000, and the maximum award is $5,000,000. • Cost sharing is required for premium instruments or special use instruments. • The estimated funding for this opportunity is $83,000,000. • The opportunity is open to various types of applicants, including private institutions of higher education, public and state-controlled institutions of higher education, and nonprofits.