Advanced Dermal Regeneration Substitutes for Treatment of Severe Burns and Complex Traumatic Injuries

The Biomedical Advanced Research and Development Authority (BARDA) is seeking information on advanced dermal regeneration substitutes for the treatment of severe burns and complex traumatic injuries. The goal is to identify innovative medical countermeasure technologies that can address large-area skin loss due to thermal burns or traumatic injuries in a mass casualty incident. Respondents are asked to provide information on their qualifications, experience, and capabilities to develop, manufacture, and store advanced dermal regenerative substitutes. The ideal product should support formation of vascularized neodermis, enable integration with host tissue, and provide an effective barrier to microbial infiltration. • The product should be suitable for full-thickness burns, complex traumatic wounds, and large surface area injuries. • It should be ready-to-use or require minimal preparation at the point of care. • The product should have a long shelf life, be stable under a range of storage conditions, and have a scalable manufacturing process. • Respondents should provide evidence of clinical safety and efficacy, regulatory status, and established or plausible reimbursement pathways.