UNifying Imaging with QUantum Entanglement (UNIQUE) Innovative Solutions Opening (ISO)

The Advanced Research Projects Agency for Health (ARPA‑H) is issuing an Innovative Solutions Opening (ISO) to fund the UNifying Imaging with QUantum Entanglement (UNIQUE) program. The effort will develop quantum‑derived imaging technologies and AI‑driven reconstruction pipelines that could transform biomedical imaging. Work is organized into two nine‑month phases, with milestones ranging from demonstrating entangled photon generation and ghost‑image reconstruction to delivering fused multimodal 3‑D datasets and a quantum‑derived imaging atlas. Funding will be through Other Transaction Agreements; proposals must include a solution summary (due Oct 29 2026) and a full proposal (due Dec 15 2026). The program is open to universities, non‑profits, and for‑profit firms (large businesses must provide cost‑share). All work must be performed in the United States, and the award will be based on scientific merit, team capability, relevance to ARPA‑H’s mission, and cost. • Build quantum‑correlated photon generation/detection hardware and demonstrate entangled‑imaging contrast. • Create AI‑based reconstruction and multimodal data‑fusion pipelines that integrate quantum observables with anatomical/functional data. • Deliver monthly technical/financial reports, raw and processed data sets, and a Phase‑2 quantum‑derived imaging atlas.