Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional)

The purpose of this Notice of Funding Opportunity (NOFO) is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders during the menopause transition. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during the menopause transition. The research should focus on aspects such as classic depressive symptoms in combination with menopause symptoms, the role of reproductive steroids in the regulation of mood and behavior, diagnosis of mood and psychosis symptoms at menopausal stage, investigation of co-occurring psychiatric and menopause symptoms, and differential diagnoses. • The funding opportunity encourages interdisciplinary researchers to collaborate on studies of mood and psychosis during the menopause transition. • The research should aim to identify targets for future development of novel treatment interventions. • The funding opportunity is open to various types of applicants, including special district governments, small businesses, native American tribal organizations, public and state-controlled institutions of higher education, and non-profits. • The expected application count is 100, and the expected application size is 0.