Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)

The purpose of this Notice of Funding Opportunity (NOFO) is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders during the menopause transition. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during the menopause transition. Aspects of mood and psychosis disorders that are of interest include classic depressive symptoms in combination with menopause symptoms, the role of reproductive steroids in the regulation of mood and behavior, diagnosis of mood and psychosis symptoms at menopausal stage, investigation of co-occurring psychiatric and menopause symptoms, and appreciation of psychosocial factors common in midlife. • The funding opportunity encourages interdisciplinary researchers to collaborate on studies of mood and psychosis during the menopause transition. • Review criteria will focus on the comprehensiveness of the neurobiology and mechanisms of action underlying mood and psychosis symptoms and hypothesis-driven work. • Eligible applicants include public and state-controlled institutions of higher education, independent school districts, county governments, city or township governments, and non-profits. • The expected application size is not specified, and the electronic submission is required.