This NIH Notice of Funding Opportunity (NOFO) invites R01 applications to conduct palliative‑care research across the lifespan for individuals with serious illness and their care partners. Applicants may propose hypothesis‑driven clinical trials (Stage II‑V of the NIH Stage Model) or non‑clinical studies such as health‑services, observational, or methodological research. Projects must align with the missions of participating NIH Institutes (e.g., NIA, NIMH, NINDS, NINR, NIMHD, NCI, NICHD, THRO) and will become members of the ASCENT Consortium. The award is a standard R01 grant with no cost‑sharing required; eligibility is broad, covering public, private, tribal, and nonprofit entities. The anticipated award period begins April 1 2027, with a typical project duration of up to five years.
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