Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)

This NIH RFA seeks to fund up to five UM1 cooperative‑agreement research centers that will develop and apply frameworks for studying non‑additive genetic and environmental interactions affecting genomic variant impact. Awardees will generate experimental data, predictive methods, and share resources through the Impact of Genomic Variation on Function (IGVF) portal, collaborating across a national consortium. • Funding: up to $1.5 M per award (total estimated funding $10 M, 5 awards). • Activity code: UM1 (complex‑structure cooperative agreement). • Eligibility: wide range of U.S. and foreign‑eligible entities (universities, nonprofits, for‑profit, small businesses, government). • Key deliverables: research framework, experimental interaction testing, data/analysis sharing via IGVF portal, predictive method publication. • Consortium participation: monthly calls, annual meetings, shared governance (Steering Committee). • Duration: multi‑year (typical UM1 awards span 4–5 years, though not explicitly stated). • Submission window: 14 Nov 2026 – 14 Dec 2026. • Contact: IGVF Program Team (nhgri‑[email protected]) and NIH program officer Mike Pazin.