Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)

The National Institutes of Health (NIH) is seeking up to five research centers to develop, apply, and test predictive computational models that assess how genomic variation influences genome function. Funded centers will join the Impact of Genomic Variation on Function (IGVF) Consortium, sharing data, tools, and analytical expertise, and collaborating on experimental design, data integration, and consortium governance. The award is a UM1 Cooperative Agreement (complex‑structure) with an estimated total funding pool of $5 million and a ceiling of $800 k per award. Applicants must submit a full application by December 14, 2026, and will be required to provide data‑management plans, annual progress reports, and participate in consortium meetings and steering‑committee activities. • Develop and validate predictive models of genomic variation impact. • Perform integrative analyses across multi‑omics data sets. • Contribute computational tools and pipelines to the IGVF resource. • Engage in consortium governance (Steering Committee, monthly calls, annual meetings). • Deliver annual research performance reports and adhere to NIH data‑sharing policies.